CV
Education
Ph.D. – Epidemiology, Biostatistics Minor October 2020 University of Minnesota, School of Public Health, Twin Cities, MN Division of Epidemiology and Community Health Thesis: “Associations between the oral and gut microbiome in response to aspirin prophylaxis”
Masters of Public Health – Epidemiology MPH, Biostatistics Minor August 2015 University of Minnesota, School of Public Health, Twin Cities, MN Division of Epidemiology and Community Health Thesis: “Trends in the incidence of testicular germ cell tumors among men in the United States and effects of agricultural pesticides exposures”
Bachelor of Arts – Medical Laboratory Science May 2012 Sanford Health Medical Laboratory Science Program, Sioux Falls, SD
Medical Laboratory Scientist Certification – ASCP Certified (May 2012)
Bachelor of Arts – Biology & Chemistry May 2011 Southwest Minnesota State University, Marshall, MN Capstone Project: “Investigation of a Streptomyces nodosus glycosyltransferase”
Work experience
Post-Doctoral Research Fellow (Israni Lab) October 2020 - Present
Hennepin Healthcare Research Institute, Twin Cities, MN Division of Nephrology
Presented 9 peer reviewed posters at local and national research conferences
Implemented an in-vitro model for bacterial drug metabolism, and maintained anaerobic core instrumentation for experiments, and filed a provisional patent entitled ”In Vitro Models for Estimating Drug Dosage” (Letters Patent of the United States Application Number 63/232,369)
Assisted with complex data requests on case control, cohort and nested case control studies and clinical trials including data management (using REDCap), data cleaning, and maintaining data dictionaries for The Microbiome and Immunosuppression in Kidney Transplantation (MISSION) study and The Deterioration of Kidney Allograft Function (DeKAF) study
Used SAS, STATA and R to incorporate genetic and molecular epidemiologic data to existing epidemiologic databases
Research Assistant (Supervised by Anna Prizment) August 2015 – October 2020
University of Minnesota, School of Public Health, Twin Cities, MN Division of Epidemiology and Community Health
- Presented 10+ peer reviewed posters at local and national research conferences
- Conducted literature review and data analysis for 5 NIH grant proposal submissions
- Provided data analysis for 8 research manuscripts, and prepared 6 research manuscripts
- Customized the QIIME2, DADA2 and MOTHUR microbiome pipelines to analyze the composition the oral and gut microbiome in a clinical trial on Effect of Aspirin on Gut Microbiome (ASMIC)
- Implemented a novel microbiome analytic approach using DADA2 and QIIME2 to identify longitudinal changes in individual health and disease associated bacterial taxa
Research Assistant (Supervised by Mike Maurer) January 2014 – May 2015
University of Minnesota, School of Public Health, Twin Cities, MN
- Department of Environmental Health and Safety
- Conducted occupational and environmental exposure monitoring at the Regis Center for Arts, the University of Minnesota Veterinary School, and the Academic Health Center
- Prepared 3 industrial hygiene and quality monitoring written reports using noise dosimetry.
- Reduced the waste generation by 70% at the University of Minnesota Regis Center for Arts by designing efficient distribution scheme for waste collection.
Skills
Bioinformatics / Data analysis / Microbiome / Inflammation / Chronic Diseases
Publications
Mohammad Haneef Khan, Guillaume C. Onyeaghala, Armin Rashidi, Shernan G. Holtan, Alexander Khoruts, Ajay Israni, Pamala A. Jacobson, Christopher Staley. Fecal β-glucuronidase activity differs between hematopoietic cell and kidney transplantation and a possible mechanism for disparate dose requirements. Gut Microbes (In Press)
Prizment AE, Onyeaghala G, Church TR. Editorial: the microbiome, aspirin and colorectal cancer-authors’ reply. Aliment Pharmacol Ther. 2020 Dec;52(11-12):1742-1743. doi: 10.1111/apt.16115. PMID: 33205872.
Prizment AE, Onyeaghala GC, Church TR. Letter: synergistic role of gut flora with aspirin to prevent colorectal cancers-authors’ reply. Aliment Pharmacol Ther. 2020 Dec;52(11-12):1758. doi: 10.1111/apt.16141. PMID: 33205866.
Prizment AE, Staley C, Onyeaghala GC, Vivek S, Thyagarajan B, Straka RJ, Demmer RT, Knights D, Meyer KA, Shaukat A, Sadowsky MJ, Church TR. Randomised clinical study: oral aspirin 325 mg daily vs placebo alters gut microbial composition and bacterial taxa associated with colorectal cancer risk. Aliment Pharmacol Ther. 2020 Sep;52(6):976-987. doi: 10.1111/apt.16013. Epub 2020 Aug 8. PMID: 32770859; PMCID: PMC7719064.
Onyeaghala G, Nelson HH, Thyagarajan B, Linabery AM, Panoskaltsis-Mortari A, Gross M, Anderson KE, Prizment AE. “Soluble MICA is elevated in pancreatic cancer: Results from a population based case-control study.” Mol Carcinog. 2017 Sep;56(9):2158-2164. doi: 10.1002/mc.22667. Epub 2017 May 24.
Onyeaghala G, Lane J, Pankratz N, Nelson HH, Thyagarajan B, Walcheck B, Anderson KE, Prizment AE “Association between MICA polymorphisms, s-MICA levels, and pancreatic cancer risk in a population-based case-control study.” PLOS one. 2019.
Onyeaghala G, Lintelmann AK, Joshu CE, Lutsey PL, Folsom A, Robien K, Platz EA, Prizment AE. “Adherence to the WCRF/AICR cancer prevention guidelines and colorectal cancer incidence among African-Americans and Whites: the Atherosclerosis Risk in Communities (ARIC) study”. Cancer. 2019.
Onyeaghala G, Lutsey PL, Demerath E, Folsom AR, Joshu CE, Platz EA, Prizment AE “Association between greater leg length and increased incidence of colorectal cancer: The Atherosclerosis Risk in Communities (ARIC) Study.” Cancer Causes and Control. 2019.
Polter E., Onyeaghala G, Lutsey PL, Folsom AR, Joshu CE, Platz EA, Prizment AE. “Prospective Association of Serum and Dietary Magnesium with Colorectal Cancer Incidence.” Cancer Epidemiology, Biomarkers and Prevention. 2019.
Teaching
Teaching Assistant Fall 2016
Pathophysiology of Human Disease (PUBH 6355) University of Minnesota, School of Public Health, Twin Cities, MN Division of Epidemiology and Community Health
- Guest lectured the cancer tumorigenesis lesson
- Facilitated weekly laboratory sections for 30+ students
- Led student discussions and exam review sessions
- Graded lab assignments, exams, and met individually with students
Teaching Assistant Spring 2018
Epidemiologic Methods II (PUBH 6342) University of Minnesota, School of Public Health, Twin Cities, MN Division of Epidemiology and Community Health
- Graded lab assignments, exams, and met individually with students
- Prepared teaching materials and provided feedback on 30+ student projects using IPUMS datasets
Teaching Assistant Fall 2018
Pathophysiology of Human Disease (PUBH 6355) University of Minnesota, School of Public Health, Twin Cities, MN Division of Epidemiology and Community Health
- Guest lectured the gut microbiome and analysis short presentation
- Facilitated weekly laboratory sections for 30+ students
- Led student discussions and exam review sessions
- Contributed to weekly FAQs on student questions over the lecture materials
- Graded lab assignments, exams, and met individually with students
Teaching Assistant Spring 2019
Epidemiologic Methods II (PUBH 6342) University of Minnesota, School of Public Health, Twin Cities, MN Division of Epidemiology and Community Health
- Co-facilitated group projects for 40+ students using IPUMS data
- Graded lab assignments, exams, and met individually with students
Teaching Assistant Fall 2019
Pathophysiology of Human Disease (PUBH 6355) University of Minnesota, School of Public Health, Twin Cities, MN Division of Epidemiology and Community Health
- Facilitated weekly laboratory sections for 30+ students
- Led student discussions and exam review sessions
- Contributed to weekly FAQs on student questions over the lecture materials
- Graded lab assignments, exams, and met individually with students