Guillaume Onyeaghala

Guillaume Onyeaghala

Data Analyst | Research Scientist | Microbiome and Chronic Disease Research

CV

Education

Ph.D. – Epidemiology. October 2020 University of Minnesota, School of Public Health, Twin Cities, MN Division of Epidemiology and Community Health Thesis: “Associations between the oral and gut microbiome in response to aspirin prophylaxis”

Graduate Minor – Biostatistics. October 2020 University of Minnesota, School of Public Health, Twin Cities, MN Division of Biostatistics and Health Sciences

Masters of Public Health – Epidemiology MPH, Biostatistics Minor. August 2015 University of Minnesota, School of Public Health, Twin Cities, MN Division of Epidemiology and Community Health Thesis: “Trends in the incidence of testicular germ cell tumors among men in the United States and effects of agricultural pesticides exposures”

Bachelor of Arts – Medical Laboratory Science. May 2012 Sanford Health Medical Laboratory Science Program, Sioux Falls, SD
Medical Laboratory Scientist Certification – ASCP Certified (May 2012, expired)

Bachelor of Arts – Biology & Chemistry. May 2011 Southwest Minnesota State University, Marshall, MN Capstone Project: “Investigation of a Streptomyces nodosus glycosyltransferase”

Work experience

Post-Doctoral Research Fellow (Israni Lab) October 2020 - Present

Hennepin Healthcare Research Institute, Twin Cities, MN Division of Nephrology

Provided data analysis and prepared 3+ research manuscripts Presented 5+ peer reviewed posters findings at research conferences Implemented an in-vitro model for bacterial drug metabolism, developed and maintained anaerobic core instrumentation for experiments, and filed a provisional patent entitled ”In Vitro Models for Estimating Drug Dosage” (Letters Patent of the United States Application Number 63/232,369) Justified research value in obtaining 3 internal and external grants totaling more than $100k in funding Directed research assistants to complete 20 experimental data collection and 2 data cleaning projects Completed complex data requests on case control, cohort and nested case control studies and clinical trials including data management (using REDCap), data cleaning, and maintaining data dictionaries for 1800+ samples in The Microbiome and Immunosuppression in Kidney Transplantation (MISSION) study and The Deterioration of Kidney Allograft Function (DeKAF) study

Research Assistant (Supervised by Anna Prizment) August 2015 – October 2020

University of Minnesota, School of Public Health, Twin Cities, MN Division of Epidemiology and Community Health

Conducted literature review and data analysis for 5 NIH grant proposal submissions. Provided data analysis for 8 research manuscripts, and prepared 6 research manuscripts. Presented 10+ peer reviewed posters findings at research conferences. Customized the QIIME2, DADA2 and MOTHUR microbiome pipelines to analyze the composition the oral and gut microbiome in a clinical trial on Effect of Aspirin on Gut Microbiome (ASMIC). Implemented a novel microbiome analytic approach using DADA2 and QIIME2 to identify longitudinal changes in individual health and disease associated bacterial taxa.

Research Assistant (Supervised by Mike Maurer) January 2014 – May 2015

University of Minnesota, School of Public Health, Twin Cities, MN

Conducted occupational and environmental exposure monitoring at the Regis Center for Arts, the University of Minnesota Veterinary School, and the Academic Health Center. Prepared 3 industrial hygiene and quality monitoring written reports using noise dosimetry. Reduced the waste generation by 70% at the University of Minnesota Regis Center for Arts by designing efficient distribution scheme for waste collection.

Skills

Bioinformatics / Data analysis / Microbiome / Inflammation / Chronic Diseases

Publications

Mohamed ME, Saqr A, Staley C, Onyeaghala G, Teigen L, Dorr CR, Remmel RP, Guan W, Oetting WS, Matas AJ, Israni AK, Jacobson PA (2024). Pharmacomicrobiomics: Immunosuppressive Drugs and Microbiome Interactions in Transplantation. Transplantation. https://doi.org/10.1097/TP.0000000000004926

Prakash A, Rubin N, Staley C, Onyeaghala G, Wen YF, Shaukat A, Milne G, Straka RJ, Church TR, Prizment A (2024). Effect of ginger supplementation on the fecal microbiome in subjects with prior colorectal adenoma. Scientific Reports, 14(1), 2988. https://doi.org/10.1038/S41598-024-52658-4

Wang S, Onyeaghala GC, Pankratz N, Nelson HH, Thyagarajan B, Tang W, Norby FL, Ugoji C, Joshu CE, Gomez CR, Couper DJ, Coresh J, Platz EA, Prizment AE (2023). Associations between MICA and MICB Genetic Variants, Protein Levels, and Colorectal Cancer: Atherosclerosis Risk in Communities (ARIC). Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 32(6), 784–794. https://doi.org/10.1158/1055-9965.EPI-22-1113

Scott P, Wang S, Onyeaghala G, Pankratz N, Starr T, Prizment AE. Lower Expression of CFTR Is Associated with Higher Mortality in a Meta-Analysis of Individuals with Colorectal Cancer. Cancers (Basel). 2023 Feb 3;15(3):989. doi: 10.3390/cancers15030989. PMID: 36765944; PMCID: PMC9913301.

Reininger KA, Onyeaghala G, Anderson-Haag T, Schladt DS, Wu B, Guan W, Dorr CR, Remmel RP, Mannon R, Matas AJ, Oetting WS, Stahler P, Israni AK, Jacobson PA. Higher number of tacrolimus dose adjustments in kidney transplant recipients who are extensive and intermediate CYP3A5 metabolizers. Clin Transplant. 2022 Dec 26:e14893. doi: 10.1111/ctr.14893. Epub ahead of print. PMID: 36571802.

Khan MH, Onyeaghala GC, Rashidi A, Holtan SG, Khoruts A, Israni A, Jacobson PA, Staley C. Fecal β-glucuronidase activity differs between hematopoietic cell and kidney transplantation and a possible mechanism for disparate dose requirements. Gut Microbes. 2022 Jan-Dec;14(1):2108279. doi: 10.1080/19490976.2022.2108279. PMID: 35921529; PMCID: PMC9351555.

Prizment AE, Onyeaghala G, Church TR. Editorial: the microbiome, aspirin and colorectal cancer-authors’ reply. Aliment Pharmacol Ther. 2020 Dec;52(11-12):1742-1743. doi: 10.1111/apt.16115. PMID: 33205872.

Prizment AE, Onyeaghala GC, Church TR. Letter: synergistic role of gut flora with aspirin to prevent colorectal cancers-authors’ reply. Aliment Pharmacol Ther. 2020 Dec;52(11-12):1758. doi: 10.1111/apt.16141. PMID: 33205866.

Prizment AE, Staley C, Onyeaghala GC, Vivek S, Thyagarajan B, Straka RJ, Demmer RT, Knights D, Meyer KA, Shaukat A, Sadowsky MJ, Church TR. Randomised clinical study: oral aspirin 325 mg daily vs placebo alters gut microbial composition and bacterial taxa associated with colorectal cancer risk. Aliment Pharmacol Ther. 2020 Sep;52(6):976-987. doi: 10.1111/apt.16013. Epub 2020 Aug 8. PMID: 32770859; PMCID: PMC7719064.

Onyeaghala G, Lintelmann AK, Joshu CE, Lutsey PL, Folsom AR, Robien K, Platz EA, Prizment AE. Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention guidelines and colorectal cancer incidence among African Americans and whites: The Atherosclerosis Risk in Communities study. Cancer. 2020 Mar 1;126(5):1041-1050. doi: 10.1002/cncr.32616. Epub 2019 Dec 24. PMID: 31873947; PMCID: PMC7021569.

Polter EJ, Onyeaghala G, Lutsey PL, Folsom AR, Joshu CE, Platz EA, Prizment AE. Prospective Association of Serum and Dietary Magnesium with Colorectal Cancer Incidence. Cancer Epidemiol Biomarkers Prev. 2019 Aug;28(8):1292-1299. doi: 10.1158/1055-9965.EPI-18-1300. Epub 2019 Jun 5. PMID: 31167754; PMCID: PMC6677594.

Onyeaghala G, Lane J, Pankratz N, Nelson HH, Thyagarajan B, Walcheck B, Anderson KE, Prizment AE. Association between MICA polymorphisms, s-MICA levels, and pancreatic cancer risk in a population-based case-control study. PLoS One. 2019 Jun 5;14(6):e0217868. doi: 10.1371/journal.pone.0217868. PMID: 31166958; PMCID: PMC6550421.

Onyeaghala G, Lutsey PL, Demerath EW, Folsom AR, Joshu CE, Platz EA, Prizment AE. Association between greater leg length and increased incidence of colorectal cancer: the atherosclerosis risk in communities (ARIC) study. Cancer Causes Control. 2019 Aug;30(8):791-797. doi: 10.1007/s10552-019-01192-0. Epub 2019 Jun 4. PMID: 31165420; PMCID: PMC6681820.

Onyeaghala G, Nelson HH, Thyagarajan B, Linabery AM, Panoskaltsis-Mortari A, Gross M, Anderson KE, Prizment AE. “Soluble MICA is elevated in pancreatic cancer: Results from a population-based case-control study.” Mol Carcinog. 2017 Sep;56(9):2158-2164. doi: 10.1002/mc.22667. Epub 2017 May 24.

Teaching

Teaching Assistant Fall 2016

Pathophysiology of Human Disease (PUBH 6355) University of Minnesota, School of Public Health, Twin Cities, MN Division of Epidemiology and Community Health

Teaching Assistant Spring 2018

Epidemiologic Methods II (PUBH 6342) University of Minnesota, School of Public Health, Twin Cities, MN Division of Epidemiology and Community Health

Teaching Assistant Fall 2018

Pathophysiology of Human Disease (PUBH 6355) University of Minnesota, School of Public Health, Twin Cities, MN Division of Epidemiology and Community Health

Teaching Assistant Spring 2019

Epidemiologic Methods II (PUBH 6342) University of Minnesota, School of Public Health, Twin Cities, MN Division of Epidemiology and Community Health

Teaching Assistant Fall 2019

Pathophysiology of Human Disease (PUBH 6355) University of Minnesota, School of Public Health, Twin Cities, MN Division of Epidemiology and Community Health